Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols

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Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols☆

Lipopolysaccharide (LPS) induces host inflammatory responses and tissue injury and has been implicated in the pathogenesis of various age-related diseases such as acute respiratory distress syndrome, vascular diseases, and periodontal disease. Antioxidants, particularly vitamin E, have been shown to suppress oxidative stress induced by LPS, but the previous studies with different vitamin E isof...

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Tocopherols and tocotrienols as vitamin E

Introduction Vitamins are chemical compounds which are components of coenzymes and non-protein ingredients of enzymes. They are essential for life and normal functioning of the body. Vitamins are supplied with food as they cannot be synthesised by the body [1]. Bad diet, impaired vitamin absorption or the use of substances such as caffeine, nicotine and medicines may lead to hypovitaminosis, th...

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Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

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Simultaneous determination of tissue tocopherols, tocotrienols, ubiquinols, and ubiquinones.

A tissue-specific distribution of the various vitamin E forms, tocotrienols and tocopherols, has been found, suggesting that these forms have unique roles in cellular functions. A sensitive procedure is described for the simultaneous determination of individual tocopherols, tocotrienols, ubiquinols, and ubiquinones using gradient high pressure liquid chromatography (HPLC) and electrochemical de...

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Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

The 2014 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D., Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Director is Lillian J. Gill, D.P.A. This re-review was prepared by Monic...

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ژورنال

عنوان ژورنال: Redox Biology

سال: 2013

ISSN: 2213-2317

DOI: 10.1016/j.redox.2012.10.002